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KMID : 0382319870070020065
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Environmental Mutagens and Carcinogens
1987 Volume.7 No. 2 p.65 ~ p.71
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Effects of Monosodium Glutamate on Unscheduled DNA Synthesis and DNA Single-Strand Breaks in Primary Cultures of Rat Hepatocytes
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김동현
양규환
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Abstract
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Cytotoxic and genotoxic potential of monosodium glutamate (MSG) were evaluated in primary cultures of rat hepatocytes. When exposed to liver cell culture continuously for 24 hr, MSG did not show any cytotoxic effects up to 0.5% (w/v) level as determined by Tryphan Blue exclusion and lactic dehydrogenase release test. MSG also did not induce unscheduled DNA synthesis or DNA single-strand breaks in hepatocyte cultures up to 1% level. No synergistic effects of MSG were observed on aflatoxin B4-induced DNA damage when 1% MSG was treated to liver cell culture along with aflatoxin B1.
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